Friday, November 30, 2012

Reality check! TV genre fans neurotic, extroverts

By Courtney Hazlett, TODAY

Ratings show us that Americans hunger for reality TV about as much as Honey Boo Boo?s family craves their infamous ketchup-and-butter-topped ?sketti.? But while we think we?ve come to know the people on the small screen in shows as varied as ?Teen Mom? and ?Deadliest Catch,? what do we know about the viewers who regularly tune in??

TODAY.com surveyed nearly 19,000 people and found those who watch reality TV consider themselves more extroverted, more neurotic, and say that they have lower self-esteem than folks who aren?t fans of the genre.

AP (2), Getty Images

Three big stars of reality TV who generate a fair share of viewer reaction are, from left, Honey Boo Boo, Mike "The Situation" Sorrentino, and Kim Kardashian.

Although both watchers and non-watchers of the genre report relatively high levels of self-esteem, the survey revealed that some viewers actively turn to reality shows to make them feel better about their own lives.

Feeling untidy because of those couple of dishes left in the sink? That?s nothing compared to what you?ll see on A&E?s ?Hoarders.?

"That?s clearly about schadenfreude?-- taking pleasure in the misfortune of others,? psychiatrist and frequent TODAY contributor Dr. Gail Saltz says. ?On the one hand, what?s wrong with feeling a little better about your house when you see someone on TV with a mess and 50 cats? On the other, it?s not a helpful defense mechanism when you have your own things going on that you should be attending to.?

Seventy percent of reality TV fans reported being extroverts compared to 59 percent of non-watchers. And 24 percent of those viewers considered themselves neurotic, compared to only 14 percent of non-watchers, the survey revealed.

?Extroverts are people who gain a lot of what they want from the outside world. Obviously watching someone else?s world is exactly that,? Saltz said. ?Neurotic people tend to be worried about how others will judge them. Then you have ?Here Comes Honey Boo Boo? -- here?s the family who?s the epitome of ?we don?t care.? That would be an enjoyable thing to watch for a person who?s walking around thinking ?I have to think about what people say.??

As one fan of the show wrote: ?It?s totally hysterical. I laugh the whole time. They have absolutely no embarrassment about anything they do and show you can be happy with very little. Sweet people.? Gross ... but sweet.?

Watching people pick through piles of garbage on ?Hoarders? may seem like a considerable decline in the evolution of the reality genre ? especially for those who grew up on the simple joy of ?Survivor.? But while competition shows certainly paved the way for unscripted programming, the TODAY survey was focused on shows like ?Real Housewives? and ?Teen Mom? -- a subset of programming where there?s no elimination along the way and no prize at the end.?

So what else did the survey tell us about the genre so many publicly snicker at, but privately watch?

  • ?Deadliest Catch??-- chronicling the high-seas adventures of crab fishermen -- is the most popular show among men, which might not come as a surprise. But the second-most popular among men? The ?Real Housewives? franchise.
  • ?Keeping Up With the Kardashians? and the ?Real Housewives? franchise were the two most popular shows among women.
  • Women are more likely than men to watch reality programming (49 percent of women versus 24 percent of men.)
  • Younger people were much more likely to watch: 19- 29-year-olds made up 70 percent of respondents.?

And sorry, Snooki, but shows like "Jersey Shore" support the concept that some reality TV leaves viewers are appalled but unable to look away. ?I like watching the train wreck,? was the common refrain.

But the allure of the train wreck only goes so far. For as pervasive as the programming seems to be, there are plenty of people not watching, and they?re not afraid to say exactly why.

?I think reality show(s) are the stupidest thing ever created for TV and a blight on society,? a non-viewer said in the survey. ?I believe [reality TV] is contributing to the dumbing down of our country and promotes bad and immoral behavior,? said another.

While there?s ample opportunity on some shows to watch pretty awful behavior, that doesn?t mean that it?s taking down civilization as a whole, one uncouth incident at a time.

Julie Klausner, who recaps ?Real Housewives of New Jersey? and ?Real Housewives of Beverly Hills? for New York magazine, said, ?I know a lot of smart people who watch ?Housewives? and ?Honey Boo Boo,? and we all have a very specific sense of status, which is, we know when it's not OK to laugh at somebody, and when it makes sense to root for them.?

Regardless of whether you think reality television can be painted with a single brush, either good or bad, the truth is millions of people continue to tune in. In 2011, ?Jersey Shore? was the most-watched cable series on television, averaging 9.3 million viewers per episode. Each new episode of ?Here Comes Honey Boo Boo? draws about a million viewers, and that number doesn?t count the number of people who watch (or re-watch) the reruns.

The laws of television programming -- if it rates, run it -- reign supreme. Until that kind of viewing trend changes, the genre probably isn?t going away.

But that doesn?t mean the makers of such programming are in a hurry to talk it up. Numerous reality TV producers and executives for the networks that run the shows were asked to comment about TODAY?s survey findings. Everyone declined.

We who watch might be as much to blame as the people who participate in the shows. David Frederick, professor of psychology at Chapman University and consultant on the TODAY survey, points out that ?we are likely hardwired to seek out information on how other people deal with conflicts, family, friends and mating.?

?Reality TV provides one source of information regarding what makes some people more susceptible to being manipulated, what makes them more prestigious, and how to survive in dangerous situations,? Frederick said. ?These shows appeal to?a very basic human need for information about social relationships.?

Decades ago, the social relationships before us -- on television at least -- might have come from the family sitcom, but the days of ?Leave it to Beaver? and even ?Friends? are long behind us. For now, for better or worse, that torch has been passed.

So for the Kardashians, the various real housewives, and you, too, ?Giuliana and Bill? -- you have our attention. Behave wisely.

Want to defend your reality-TV-watching habit, or take issue with the genre? Join the discussion on Facebook.

Related content:

Source: http://todayentertainment.today.com/_news/2012/11/29/15459956-reality-check-for-reality-tv-fans-youre-more-neurotic?lite

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NASA finds new evidence of ice in Mercury's polar craters

NASA finds new evidence for ice in Mercury's polar craters

While the Mars Curiosity rover has garnered most of our space-gazing attention lately, another of NASA's spacecraft has made quite a momentous discovery on an entirely different planet. The Messenger space probe (which stands for MErcury Surface, Space ENvironment, GEochemistry and Ranging) has found new evidence for ice on Mercury, which is surprising given its proximity to the sun. Thanks to a subtly tilted axis, many of the planet's polar craters never see the light of day, and can dip to temperatures as low as minus 370 Fahrenheit. Indeed, scientists claim there's 100 billion to 1 trillion tons of ice on Mercury -- David Lawrence, a Messenger participating scientist, said that "if spread over an area the size of Washington, D.C., [the ice] would be more than two miles thick." The Messenger, which only started orbiting Mercury last year, helped confirm scientists' conclusions by capturing detailed images of the planet's surface, measuring the craters' reflectivity and utilizing a neutron spectrometer that discovered the presence of excess hydrogen. Scientists even found slightly warmer regions on Mercury that might be temperate enough for, well, a colony: "People joke about it, but it's not so crazy, really," said David A. Paige, a UCLA professor quoted in the New York Times. Of course, this is assuming we don't boil or freeze to death on our way there. For more information about the find, check out the press release below.

Continue reading NASA finds new evidence of ice in Mercury's polar craters

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Source: John Hopkins University APL, New York Times, NASA


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Boehner joins filibuster fight against Democrats

House Speaker John Boehner of Ohio arrives to speak to reporters on Capitol Hill in Washington, Thursday, Nov. 29, 2012, after private talks with Treasury Secretary Timothy Geithner on the fiscal cliff negotiations. Boehner said no substantive progress has been made between the White House and the House" in the past two weeks. (AP Photo/J. Scott Applewhite)

House Speaker John Boehner of Ohio arrives to speak to reporters on Capitol Hill in Washington, Thursday, Nov. 29, 2012, after private talks with Treasury Secretary Timothy Geithner on the fiscal cliff negotiations. Boehner said no substantive progress has been made between the White House and the House" in the past two weeks. (AP Photo/J. Scott Applewhite)

(AP) ? House Speaker John Boehner joined fellow Republicans in the Senate on Thursday in their battle to stop Democrats controlling that chamber from curbing filibusters, threatening to ignore bills the Senate sends him if Democrats have abused GOP senators' rights to slow consideration of legislation.

The threat by Boehner, R-Ohio, represents an unusual escalation across the Capitol building of a bitter partisan fight that has been brewing in the Senate for weeks. It also underscores a Republican effort to retain as much power as they can next year, when Democrats will control the White House and Senate and Republicans will lead only the House.

Senate Majority Leader Harry Reid, D-Nev., has said that on the first day of the new Congress in January, he may take the unusual step of using a simple majority vote to limit filibusters.

Usually it takes a two-thirds vote to change Senate rules. A simple majority would mean Democrats could change the filibuster rules without GOP support, and the threat has infuriated Senate Minority Leader Mitch McConnell, R-Ky., and other Republicans. Democrats will control the new Senate 55-45, including one Democratic-leaning independent.

Boehner said that Reid's threat "is clearly designed to marginalize Senate Republicans and their constituents while greasing the skids for controversial, partisan measures."

He added, "Any bill that reaches a Republican-led House based on Senate Democrats' heavy-handed power play would be dead on arrival."

Though the rules change would not occur until next year, Boehner suggested that it might poison the atmosphere even sooner, "at a time when cooperation on Capitol Hill is critical."

President Barack Obama and congressional leaders of both parties are currently bargaining over deficit-cutting measures that would avoid the so-called fiscal cliff of big tax increases and deep spending cuts scheduled to begin in January unless lawmakers find a way to avert them.

Minority parties in the Senate use filibusters ? parliamentary delays ? to slow or kill legislation. They can only be ended by 60 votes ? a margin neither party can achieve without some cooperation from the other side.

Democrats say Republicans are abusing filibusters by resorting to them too frequently, and statistics show minority Republicans have increasingly used the tactic in recent years. Reid's plan would forbid the use of filibusters when a bill is initially being brought to the Senate floor for debate and require filibustering senators to actually be on the Senate floor, a long-abandoned practice.

"It is a shame to see Speaker Boehner join Sen. McConnell's desperate attempt to double down in the status quo of Republican-led gridlock in Washington," said Reid spokesman Adam Jentleson.

Republicans say they have used filibusters more because Reid blocks them from presenting amendments. Reid, in turn, says Republicans use too much time pushing amendments that make political statements or that are designed to derail bills.

The battle has prompted numerous sharp exchanges on the Senate floor in recent days between Reid and McConnell.

Neither side has ruled out negotiating a solution to the dispute.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2012-11-30-US-Filibuster%20%20Fight-Boehner/id-a1d2c7b4d01d4c119707a1aa66dff588

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Wall section collapses in Pompeii after heavy rain

(AP) ? The Italian news agency ANSA says a wall at the Pompeii archeological site has collapsed following days of heavy rain.

The collapse Friday of a two-meter (six-foot) section of wall in an area closed to tourists is the latest in a series that has raised concern about the state of the cultural treasure. In 2010, a 2,000-year-old house collapsed in the ancient Roman city that was once used by gladiators to train before combat.

The Italian government and the European Commission last spring announced a project to spend ?105 million ($136 million) to secure the Pompeii site.

Some 3 million people each year visit the ancient city south of Naples that was destroyed in A.D. 79 by a volcanic eruption from Mount Vesuvius.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-11-30-Italy-Pompeii%20Collapse/id-81cb601f0ea34f2e82faaa5cca06846c

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HIStalk Interviews Kobi Margolin, Founder and CEO, Clinigence ...

Jacob ?Kobi? Margolin is founder and CEO of Clinigence of Atlanta, GA.

11-28-2012 4-02-40 PM

Tell me about yourself and about the company.

I?m the CEO and founder Clinigence, my third venture in healthcare IT. I am semi-Americanized, an Israeli originally. In the mid-1990s after seven years in an intelligence branch of the Israeli Defense Forces with a group of colleagues that I met in the military, we started Algotec, a medical imaging company. With Algotec, I came to Atlanta in 1999 to start US operations.?

We sold the company to Kodak in 2004. I then joined a startup at Georgia Tech that focused on the Software-as-a-Service (SaaS) model in medical imaging.

At my first company, Algotec, we were pioneers of bridging web technologies into the PACS market. These were days when medical imaging went through the electronic revolution. Our technology was all about distributing clinical images across the enterprise and beyond. My second company, Nurostar Solutions, capitalized on this electronic revolution and the SaaS model to facilitate new business models for imaging services. In those days, teleradiology was exploding and we became the leading technology platform for these services.

In 2008, I started on a path that led me to Clinigence today. 2008 was an election year. In the days leading to that election, I looked at what was going on in the market and thought that there might be new opportunities opening up around electronic medical records. I had followed the EMR market since my first HIMSS in 1997 in San Diego. The market was advancing, as one of the analysts put it, at glacial speed. Then in 2008 or 2009, suddenly an explosion of funds was allocated for this market. I started thinking about what was coming next. Let?s assume that the market is already on electronic medical records. What impact is that going to have?

That led me to the concept of clinical business intelligence, which in essence is, how do we make sense of the data in electronic medical records from both the clinical and business or financial standpoint for the benefit of healthcare providers, for the benefit of medical practices and their patients? This is when we started Clinigence.

Officially started in 2010, we had our first beta in February 2011 and our first commercial installation in October 2011. Today we are in over 70 medical practices with about 400,000 patients on the platform, with two EMR companies as channel partners. We just signed our second partner a few weeks ago and our first ACO customer just a few days ago.

?

How do you position yourself in the market and who do you compete most closely with?

In the clinical analytics industry, we are unique in that we are entirely provider centric. We jumped into clinical analytics with the vision that everything is going to be inside clinical operations and everything is going to be electronic. We have created a technology foundation that uses electronic medical record data as its primary source.

If you look at clinical analytics, that is a multi-billion dollar industry. Pretty much all of that industry has focused on healthcare payers or health plans. The technologies are based on administrative or claims data. There are specific benefits ,we believe, in the use of EMR data as your primary source. The number one differentiator for us is in the use of EMR data, which allows us to do three things.

Number one, our reports are real time. We create a real-time feedback loop that takes the data from the provider system and goes back to the providers and helps them change the way they deliver care to their patients in more proactive ways.

Number two, our reports are very rich in outcomes. We all know that the ultimate goal of everything we?re doing in health reform today and healthcare transformation is patient outcomes. Yet a lot of the reports you look at today in the market don?t give you any outcomes in them, because the data that?s used to generate them is data for billing purposes that doesn?t include clinical outcomes.

Number three, because we focus on the system that comes from the healthcare provider organization itself, we give providers the ability to break the report all the way down to individual patients and individual clinical data elements. The reports are not anonymous for them. The reports are something that they can trust, something they can work with. With that, we have the power to change the behavior of providers and affect behavior change in their patients, which improves outcomes.

?

If a physician is receiving reports from your system, what kind of improvements might they suggest?

The reports from our system drive a process, the process of improvement. It?s like peeling layers of an onion. We focus today almost exclusively on primary care. When we go to a primary care practice, we first have the physicians look at how they document clinical encounters today.?

Oftentimes the outer layer of the onion is helping the practice or the individual physicians with their documentation practices ? making sure that they?re documenting everything that needs to be documented. We often find that physicians say, ?Oh, we do these things,? but when you look down at their report, it doesn?t show it. It turns out that they?re doing things, but they?re not always documenting them or not documenting them correctly.

Then the second layer is we help the practices compare their performance, the compliance of their staff, with medical guidelines, recommended care, and sometimes their own protocols within the organization or the practice. You go into a practice and you ask the doctors, ?Do you follow these protocols??

For example, in family medicine, diabetes is chronic disease number one. The recommended guidelines, recommended care protocols for diabetes are pretty well established. We know the things we need to do. You go in and ask the physicians and they always say, ?Of course we follow medical guidelines. Of course we do all the things that we?re supposed to.?

Then you start breaking the data down to reports across the organization, across the staff within the practice. Almost inevitably you find that there are variations in care, differences among providers and their compliance with these protocols which lead to gaps in individual patient care. We help them find these variations in process compliance, close these gaps, and improve their compliance with those medical guidelines and protocols.

The deepest layer of the onion, which only a few of the practices we?re working with are at that level ? certainly in the ACO market we think that there?s going to be more of that ? is about going into the effectiveness of your protocols within the practice in driving outcomes and that goes both to patient outcomes and eventually to business or financial outcomes for the practice. In this context, we give the customer the power, essentially, to do things like comparative effectiveness, look at various protocols that they use and see which ones are driving the outcomes or the results that they want.

?

The ACO concept is new enough that I?m not sure anybody really understands how they?re going to operate. Does anybody know how to use the data that you?re providing to manage risk, specifically within an ACO model? Or is it just overall quality and that?s what ACO should encourage?

I think that the ACO market is indeed still a baby. OK, it?s a newborn. Everybody is at the beginning of a journey. Even some of the organizations that have been doing this for the longest, like the pioneer ACOs, are still in very early stages.

We are focusing in the ACO market on finding organizations that we think have the best shot of going through this journey and being successful in going through this journey. We come to them and offer them a partnership in the journey, where we become somewhat of a navigation system for them with the kind of reports I mentioned earlier. Then really all that our technology can do ? empower them with those navigation tools to find the roads that lead to the holy grail of accountable care, to find the roads to the triple aim of health reform.

As I?ve said, we?ve just closed our first ACO customer, so it?s going to be presumptuous of me to say, ?Yes, the answers are already there.? But with the three things that I mentioned earlier, specifically, primary care driven and physician-led ACOs have unique potential of identifying, figuring out the ways to get to that holy grail. We think that our technology is a critical piece that can help them and then accelerate them in their path towards that holy grail.

?

Describe the patient-centered medical home model and the data capabilities physicians need to operate under that.

In primary care, we are doing much more work on medical homes than ACOs because ACOs are still few and far between. There is great interest in the patient-centered medical home model.

The patient-centered medical home model in itself is only a care delivery model. It does not come with a payment model attached to it, but there are certain markets where payers actually offer incentives to those practices that go to the patient-centered medical home model.

To become a patient-centered medical home, there are specific areas that the practice needs to address. NCQA offers a certification process that has become the de facto standard in certification as a medical home. They don?t necessarily force you to have an electronic medical record, so you can potentially become a patient centered medical home even without one. But what we would say is, as you look at your goals in the patient-centered medical home ? specifically goals around continuous quality improvement, goals around population health management ? using electronic medical records becomes necessary, a prerequisite to your ability to engage seriously in those kinds of efforts.?

We typically come in with our technology after the practice implements or adopts electronic medical record technology and help them take the data in their electronic medical record and translate that into a clear path towards quality improvement.

?

Is it hard to get physicians to follow your recommendations?

Most physicians are independent. They don?t like to be told what to do. Before I started Clinigence, I looked at clinical decision support and decided not to jump into it, basically because I didn?t want to be in a position to tell physicians what to do. Instead, I selected clinical business intelligence. It was more around telling physicians how well they?re doing and how well their patients are doing.?

One of the unique aspects of what we?ve built is that we created a ?declarative classification engine,? which in essence means that the physicians can ask the system whatever question they want about their operations, about their patients, about their quality. We give them flexibility to go around the medical guidelines that come from the outside sources, build their own protocols, and then look at compliance and look at their performance relative to the protocols that they have set up for themselves.

You have to be somewhat careful when you do that. If you?re looking for success under a specific pay-for-performance program, then you have to abide by whatever the payer or some outside authority has set for you, and it is not uncommon for us to have variations or flavors of the same guideline. One that measures performance for the outside reporting purpose, and then a second one or even a number of them that give the practice the ability to create their own flavor of protocols.?

Then it?s no longer somebody telling you ? Big Brother telling you ? what to do. You have the power to determine what to do. I think the ACO model ? and to some degree, also the patient-centered medical home as a step towards the ACO model ? puts the physicians within those ACOs in the driver?s seat. Nobody is telling them where to go or what road to try in order to drive the success of the ACO.

There are 33 quality metrics for an ACO that are defined by Medicare. We say, ?Is this sufficient?? Clearly these metrics are necessary; you have to report on those to Medicare. But are these sufficient? Will these guarantee your success??

It is clear to everybody in the ACO market that the answer is no. These may provide a starting point, but nothing more than that. You have to carve your own way to achieve the outcomes. We know what outcomes are desired, but as far as how to get there, much is still unknown. There?s great need for innovation in fact in the market to figure it out.

?

A number of Israel-based medical technology companies have come in to the U.S. market, a disproportionate number based on what you might expect. Why are companies from Israel so successful in succeeding here?

My personal story may be a bit of a reflection of the success story of Israeli medical technology. Israel has become a Silicon Valley, an incubator of technology. Israel has more technology companies on Nasdaq, I think, than all of Europe combined. A lot of it is around the medical field.

Why has Israel has become that? I can speak from my own personal experience. There?s a book called Start-up Nation that was written by Dan Senor that looked more generally at this same question. His thesis in the book is that the military in Israel is the real incubator, the real catalyst for innovation.

I can say from my experience it really was like that. In my first company, Algotec, we started fresh out of the military. We were a group of engineers in the military. We knew very little about healthcare, certainly not healthcare in the US.

What we knew ? and what the military instilled in us ? was the desire to do something, to innovate, to create something. Beyond the desire, also the confidence to think that at the early age and early in our careers as we were back then, that we could do something like that. We could go and make a difference like that.?

There?s a lot of that going on in the medical field. I joke around that every Jewish mother wants her kid to be a doctor. Certainly there?s a lot of that here in the States. When I was growing up, somehow I was never really attracted to that. I was more on the exact scientific side. For my undergrad, I chose math and physics. In grad school, medical physics for me was a way to bridge the gap, to fulfill at least a portion of the wishes of my mother.

?

Any concluding thoughts?

You asked me about the process that we go with practices and I said it?s like peeling layers of an onion. Today, mostly with our clients we focus with them on some of the outer layers. We help them comply with pay-for-performance or create a patient-centered medical home.?

But where I think all of this gets really exciting and interesting is when you start getting to the deeper layers. We took great efforts to build a platform that?s very flexible. The unique piece I mentioned earlier in this context was the declarative classification engine. We also built what we believe is the first commercial clinical data repository that?s based on semantic technologies. Now this may sound to some folks like technology mumbo jumbo, but what?s important here is the ability to get data ? any type of data ? and make sense of it, so the system can understand the data even if it has never seen data like that before.

We think that over time, as our healthcare system goes through this journey of figuring out how to deliver more effective and efficient care, we can with technologies like that drive or create a bridge in between medical practice and medical science or medical research. Imagine that all of medical research ? pharmaceuticals that go to the market or new devices that go through clinical trials ? where they test the devices on hundreds or thousands of patients. We are building a system that can collect data from many millions of patients. Already today we are collecting data on hundreds of thousands of patients every day in medical practices.

Imagine what kind of insights we can get out of the data that we?re collecting, and then how this can then accelerate medical knowledge. Not just in the context of the holy grail of accountable care ? helping deliver care that?s more efficient and effective ? but really advancing medical science, identifying new things, new treatment protocols that otherwise we would never know about or would take us generations potentially to find.

Source: http://histalk2.com/2012/11/28/histalk-interviews-kobi-margolin-founder-and-ceo-clinigence/

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Bailey set as women's league executive director

Associated Press Sports

updated 7:57 p.m. ET Nov. 29, 2012

CHICAGO (AP) - Former U.S. women's national team general manager Cheryl Bailey will serve as the executive director of the new U.S. Soccer-led women's league that will begin play next year.

U.S. Soccer President Sunil Gulati announced the appointment Thursday.

"Cheryl was a highly regarded employee for U.S. Soccer during her time with the women's national team and she has the perfect skill set and experience to help get this league up and running," Gulati said.

Bailey was the general manager of the U.S. women's national team from 2007-2011.

"It was a wonderful experience to be a part of the women's national team for five years and see firsthand the impact that women's soccer players can have as role models," Bailey said. "The new league is another extension of that and a vitally important part of the continued growth of the sport in the United States."

The eight-team league will have teams in Boston, Chicago, New Jersey, Portland, Seattle, Kansas City, western New York and Washington.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Real-Time Genetics Could Squash "Superbug" Outbreaks before They Spread

track superbug outbreak real time genetic sequence

Image of MRSA courtesy of Wikimedia Commons/Janice Haney Carr, Centers for Disease Control and Prevention

Genetic sequences of drug-resistant bacteria have helped scientists better understand how these dastardly infections evolve?and elude treatment. But these superbugs are still claiming lives of many who acquire them in hospitals, clinics and nursing homes. And recent outbreaks of these hard-to-treat infections can spread easily in healthcare settings.

Researchers might soon be able to track outbreaks in real time, thanks to advances in sequencing technology. So say Mark Walker and Scott Beaston, both of the School of Chemistry and Molecular Biosciences and Australian Infectious Disease Research Center at the University of Queensland in Australia, in an essay published online November 29 in Science. ?Genomic sequencing can provide information that gives facilities a head start in implementing preventive measures,? they wrote.

Current preventive measures, such as increasing healthcare worker hand washing and isolating infected patients, have helped to reduce the spread of many healthcare-acquired infections. But these preventable infections still kill some 100,000 patients in the U.S. each year.

Walker and Beatson think genomics has the capacity to ?revolutionize current practice in clinical microbiology,? which currently relies primarily on culturing pathogens in the lab to study strain differences?a time-consuming process. Some promising examples have already emerged.

A 2011 outbreak of Klebsiella pneumoniae (KPC), which is resistant to most known antibiotics, at the National Institutes of Health?s Clinical Center killed 11 patients and infected many others. Genetic sequencing of samples from patients and from healthcare workers allowed epidemiologists to track the outbreak to a single patient and to trace its spread.

The KPC analysis even pinpointed a transmission event in which a contaminated ventilator was used on a new patient. This level of detail points to the ability of ?genome sequencing-based epidemiology to influence hospital management practices,? the researchers noted.

These discoveries, however, were made after the outbreak was underway. ?In a real-time clinical situation, this information would enable further targeted testing of other patients or healthcare professionals to identify intermediate carriers,? Walker and Beatson wrote.

Moving closer to real-time tracking, researchers sequenced and analyzed strains from a 2011 outbreak of methicillin-resistant Staphylococcus aureus (MRSA) in a neonatal intensive care unit in Cambridge, in the U.K., while the outbreak was still occurring. A local clinical microbiologist wondered whether infants who had contracted the superbug had strains related to those currently circulating in other clinics and hospital areas. A team sequenced samples and found that not all of the strains were related, but that there was indeed a clear outbreak cluster in the neonatal unit. The microbiologists were then able to trace potential means of spread and thereby reduce the risk of further spread. The genetic sequencing, completed on a bench-top sequencer, also provided information about the strain?s virulence and nature of its antibiotic resistance.

These instances ?point to a future in which direct sequencing of clinical samples allows same-day diagnosis, antibiotic resistance gene profiling and virulence gene detection,? Walker and Beatson noted. Such sequencing and analysis is still too expensive and labor-intensive for most health care institutions. But as technologies improve, putting the tools within reach, clinical microbiologists might be soon able to stop these superbug outbreaks before they start.

Source: http://rss.sciam.com/click.phdo?i=e34fd2a768a306920b3ba9f98881fdc9

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Social Media and Purpose-Brand Promotion by a Business ...

Photo: Boys Green Eye Credit: Loredana Bejerita

Most people understand that companies operate to sell and make a profit. Their first and primary purpose is not an altruistic charity drive or grant program but in fact to earn a margin of revenue above the cost of production and use that money to grow and expand. However, when that first Maslow Hierarchy-type purpose is immediately met, companies can and often do marry their business function with a particular goal or purpose. With the recent wave of businesses moving online to have presence in social media, the idea of a brand and purpose along with profit is becoming more and more prevalent. However, aside from creating a lot of content for viewers to look at, the question frequently comes up as to how all this effort improves the company?s bottom line.

There is no question that increasing consumer awareness improves brand recognition which can also have an indirect boost on profitability. If done right, name and logo recognition gets associated with various marketing messages, driving consumers to purchase the service or product involved because of the implied or expressed connection. Purpose, beyond the company mission and primary goals for making profit, tends to be a temporary campaign that ultimately is associated with either maintaining a given brand awareness level or improving it.

However, social media has been a bit of quandary to the traditional game book. The format works very well as a platform on which to express messaging and brand marketing virally. It?s practically natural for viewers and readers to share information through Internet connection, spreading the messaging put out on an exponential level. As a result, companies and their marketing managers have dived in wholesale to social media tools. That said, purpose is harder to coalesce and form in the social media environment. Most readers pick up quickly a given business exists to sell a product or service, but if the messaging is not clear, other purposes come out confused and disconnected. Much of the problem has to do with business? strategy towards social media in general.

Social media is typically seen as just another communication tool for many businesses, albeit one that seems to take more time and energy to do properly. The mindset tends to assume that if enough resources are put to the task, some kind of business growth output will occur and purpose will be met. Unfortunately, social media doesn?t work this way; readers don?t necessarily follow a formulaic response to social media posts and chirps. They comment back, they share, they digress, and they even create their own social media pages in response to a business? presence if highly motivated. And 99 percent of that response is uncontrollable for a business.

Instead, before entering social media, a company needs to understand the virtual environment requires an ongoing commitment to make social media tools produce a desired social good with brand awareness. Second, the company needs to have defined purposes that are clearly laid out to readers and followed consistently by those inputting the social media content. Doing so creates consistency and repetition of messaging over time. Eventually, the company?s brand gets associated with the given social good because the relationship is solidified repeatedly to viewers at all levels.

Profitability is not guaranteed by any baseline ratio when using social media, and in some cases specific social media content will have no measurable impact on sales or new revenue production. That said, as a company makes a long-term commitment to a given direction with its social media messaging, people accept over time that a company supports this charity, focuses on that program, helps the community in a given way, etc. The synonymous assumption becomes en-grained, much the same the local street store owner knows everybody in a community, and their parents, and their grandparents. That type of brand awareness becomes as valuable as gold in terms of social currency because it automatically draws like-minded people into a business.

An executive who after spending 26 years in the corporate world in various marketing roles within one of the largest utilities in the nation, grew tired of the grind and sought a new challenge. Randy entered the non-profit market taking the position of Director of Marketing and Corporate Relations for a national organization, overseeing all brand and touch elements; print, web, TV and national convention. In 2010 Randy and his wife, Shalah, also a professional marketer formed bowden2bowden llc, a marketing and brand consultancy firm. Their extensive knowledge of marketing, branding, PR, advertising, promotions, relational & social networking can connect the client to targeted solutions. Clients receive exceptional creative executions and solid branding strategies giving them a real competitive advantage. Randy writes weekly for their bowden2bowden blog.

Source: http://leaderswest.com/2012/11/30/social-media-and-purpose-brand-promotion-by-a-business/

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College football coaching hires lean toward offense

In recent seasons, coaching hires across college football have heavily leaned toward candidates with a background on offense.

Here's a breakdown of the last three seasons of hires at BCS schools.

Following 2011 season

School; Coach hired; Background

Arizona; Rich Rodriguez; Offense

Arizona State; Todd Graham; Defense

Arkansas; John L. Smith; Defense

Fresno State; Tim DeRuyter; Defense

Illinois; Tim Beckman; Defense

Kansas; Charlie Weis; Offense

Mississippi; Hugh Freeze; Offense

North Carolina; Larry Fedora; Offense

Ohio State; Urban Meyer; Offense

Penn State; Bill O'Brien; Offense

Pittsburgh; Paul Chryst; Offense

Rutgers; Kyle Flood; Offense

Texas A&M; Kevin Sumlin; Offense

UCLA; Jim Mora; Defense

Washington State; Mike Leach; Offense

Following 2010 Season

School; Coach hired; Background

Source: http://feedproxy.google.com/~r/Newsok/Sports/Osu/~3/82p2b89P1jA/3732807

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X-rays expose blueprint for possible sleeping sickness drug

X-rays expose blueprint for possible sleeping sickness drug [ Back to EurekAlert! ] Public release date: 29-Nov-2012
[ | E-mail | Share Share ]

Contact: Thomas Zoufal
presse@desy.de
49-408-998-1666
Helmholtz Association of German Research Centres

First new biological structure solved by a free-electron laser

This release is available in German.

Using the world's most powerful X-ray laser, scientists have exposed a possible Achilles' heel of the sleeping sickness parasite that threatens more than 60 million people in sub-Saharan Africa. The sophisticated analysis revealed the blueprint for a molecular plug that can selectively block a vital enzyme of the parasite Trypanosoma brucei. Plugging such a tailor-made molecule into the right place of the enzyme would render it inactive, thereby killing the parasite. The team led by DESY scientist Prof. Henry Chapman from the Center of Free-Electron Laser Science (CFEL), Prof. Christian Betzel from the University of Hamburg and Dr. Lars Redecke from the joint Junior Research Group "Structural Infection Biology using new Radiation Sources (SIAS)" of the Universities of Hamburg and Lbeck report their findings in the journal Science. "This is the first new biological structure solved with a free-electron laser," said Chapman.

The researchers had investigated tiny crystals of the parasite's enzyme cathepsin B with intense X-rays from the free-electron laser Linac Coherent Light Source (LCLS) at the US National Accelerator Laboratory SLAC in California. "The enzyme had emerged as a promising drug target in earlier trials", said Redecke, one of the first authors of the scientific paper. "The knockdown of this essential enzyme in the parasite did cure the infection in mice."

But the same enzyme is also part of the human - and in fact of all mammalian - biochemistry, and blocking it has severe consequences. With their analysis the scientists could now pinpoint distinctive structural differences between the human and the parasite's form of the enzyme. "This should in principle allow for designing a molecule that selectively blocks the parasite's enzyme while leaving the patient's intact", explained the other first author of the paper, Karol Nass, PhD student at the Hamburg School for Structure and Dynamics in Infection (SDI), funded by the Excellence Initiative of the German Federal State of Hamburg (LEXI), The researchers stress that while the finding raises hopes, a possible new drug is still a long way to go.

Sleeping sickness, or human African trypanosomiasis (HAT), is transmitted by the bite of the tsetse fly. The Trypanosoma parasites invade the central nervous system, and without treatment the infection is usually fatal. The disease occurs in 36 sub-Saharan countries and affects mostly poor populations living in remote rural areas. Thanks to intensified control measures the number of reported cases fell steeply in recent years, but there are still millions at risk. Current treatments of HAT rely on anti-parasitic drugs developed without knowledge of the biochemical pathways. They are not always as effective and as safe as desired, and the parasites are increasingly becoming resistant to these drugs. New drugs that selectively kill the parasite without affecting the patient's own organism would be of great use.

With cathepsin B the scientists applied a novel approach by investigating tiny crystals of the enzyme that were grown in insect cells in vivo. This way the enzyme was frozen in its natural configuration that includes a native inhibitor. Because cathepsin B works as a sort of molecular scissors cutting away at other proteins, it is produced by the cell in an inhibited form and only activated when needed. In the inhibited form a small peptide molecule is blocking the cutting edge of the molecular scissors. "With the peptide still in place we could peer below a previously impenetrable part of the cathepsin B structure ", explained Betzel. There, the analysis revealed significant differences between the peptide binding sites at the parasite's and the human form of cathepsin B. "This way, nature provided us with a blueprint of what an artificial inhibitor for the parasite's enzyme could look like." The next step would be to synthesise such a tailor-made plug and test it in the lab.

The molecular structure of the enzyme was solved to the atomic level by shooting bright X-ray flashes at the tiny cathepsin B crystals, which were only about a micron (a thousandth of a millimetre) in diameter and about ten microns long on average. Crystals scatter X-rays in a characteristic way that depends on their inner structure. From the resulting diffraction pattern the structure of the crystals can be calculated, in this case revealing the structure of the enzyme. Today, crystallography is a standard technique to analyse biomolecules. Usually, scientists use modified bacteria to produce biomolecules in large amounts and try to crystallise them into the largest possible sizes of high-quality crystals afterwards. The in vivo crystallisation pioneered at the labs of Betzel and Prof. Michael Duszenko at the University of Tbingen, who is also a member of the research team, employs living cells to produce crystals. In contrast to standard crystallisation experiments, only in vivo crystallisation yielded suitable crystals of cathepsin B in a natively inhibited form.

But the in vivo crystals are still so small that only X-ray lasers like LCLS are bright enough to produce sufficiently detailed diffraction images. The LCLS belongs to a novel class of scientific light sources called free-electron lasers that are based on powerful particle accelerators. In these machines, electrons are accelerated to high speeds, or energies, and are then forced on a tight slalom course. In every bend each electron emits a tiny flash, and all the flashes add up to an incredibly strong X-ray pulse with laser properties, that allows to resolve structures like the natively inhibited cathepsin B molecule.

To solve the cathepsin B structure the researchers had to record hundreds of thousands of diffraction images that were painstakingly stitched together afterwards. As each crystal is destroyed when hit by the powerful X-ray flash, the team fed a stream of crystals in a watery solution through a thin nozzle into the laser path. The X-ray laser fired away at 120 shots per second, where on average only every eleventh shot actually hit a crystal. This resulted in a total of 293,195 diffraction images recorded. These could only be processed with massive parallel computing, to first generate a three-dimensional map of the entire diffracting signals of the enzyme from which an image of its structure was calculated. The final result revealed the enzyme's structure with a resolution of 2.1 ngstrm (one ngstrm is a tenth of a nanometre or a ten-millionth of a millimetre). "Interestingly, this discovery comes exactly at the centenary of the publication of the famous X-ray diffraction equation by William Bragg in 1912," Chapman pointed out.

The team included members from DESY, the Universities of Hamburg, Lbeck, Tbingen, Uppsala and Gothenburg, the Arizona State University, SLAC, Lawrence Livermore National Laboratory, the Max Planck institute for medical research in Heidelberg and the Max Planck advanced study group at CFEL. CFEL is a joint venture of DESY, the Max Planck society and the University of Hamburg. DESY is the leading German accelerator centre and one of the leading worldwide.

###

Reference: "Natively inhibited Trypanosoma brucei cathepsin B structure determined using an x-ray laser"; Lars Redecke, Karol Nass et al.; Science, 2012 (advance online publication); DOI: 10.1126/science.1229663


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


X-rays expose blueprint for possible sleeping sickness drug [ Back to EurekAlert! ] Public release date: 29-Nov-2012
[ | E-mail | Share Share ]

Contact: Thomas Zoufal
presse@desy.de
49-408-998-1666
Helmholtz Association of German Research Centres

First new biological structure solved by a free-electron laser

This release is available in German.

Using the world's most powerful X-ray laser, scientists have exposed a possible Achilles' heel of the sleeping sickness parasite that threatens more than 60 million people in sub-Saharan Africa. The sophisticated analysis revealed the blueprint for a molecular plug that can selectively block a vital enzyme of the parasite Trypanosoma brucei. Plugging such a tailor-made molecule into the right place of the enzyme would render it inactive, thereby killing the parasite. The team led by DESY scientist Prof. Henry Chapman from the Center of Free-Electron Laser Science (CFEL), Prof. Christian Betzel from the University of Hamburg and Dr. Lars Redecke from the joint Junior Research Group "Structural Infection Biology using new Radiation Sources (SIAS)" of the Universities of Hamburg and Lbeck report their findings in the journal Science. "This is the first new biological structure solved with a free-electron laser," said Chapman.

The researchers had investigated tiny crystals of the parasite's enzyme cathepsin B with intense X-rays from the free-electron laser Linac Coherent Light Source (LCLS) at the US National Accelerator Laboratory SLAC in California. "The enzyme had emerged as a promising drug target in earlier trials", said Redecke, one of the first authors of the scientific paper. "The knockdown of this essential enzyme in the parasite did cure the infection in mice."

But the same enzyme is also part of the human - and in fact of all mammalian - biochemistry, and blocking it has severe consequences. With their analysis the scientists could now pinpoint distinctive structural differences between the human and the parasite's form of the enzyme. "This should in principle allow for designing a molecule that selectively blocks the parasite's enzyme while leaving the patient's intact", explained the other first author of the paper, Karol Nass, PhD student at the Hamburg School for Structure and Dynamics in Infection (SDI), funded by the Excellence Initiative of the German Federal State of Hamburg (LEXI), The researchers stress that while the finding raises hopes, a possible new drug is still a long way to go.

Sleeping sickness, or human African trypanosomiasis (HAT), is transmitted by the bite of the tsetse fly. The Trypanosoma parasites invade the central nervous system, and without treatment the infection is usually fatal. The disease occurs in 36 sub-Saharan countries and affects mostly poor populations living in remote rural areas. Thanks to intensified control measures the number of reported cases fell steeply in recent years, but there are still millions at risk. Current treatments of HAT rely on anti-parasitic drugs developed without knowledge of the biochemical pathways. They are not always as effective and as safe as desired, and the parasites are increasingly becoming resistant to these drugs. New drugs that selectively kill the parasite without affecting the patient's own organism would be of great use.

With cathepsin B the scientists applied a novel approach by investigating tiny crystals of the enzyme that were grown in insect cells in vivo. This way the enzyme was frozen in its natural configuration that includes a native inhibitor. Because cathepsin B works as a sort of molecular scissors cutting away at other proteins, it is produced by the cell in an inhibited form and only activated when needed. In the inhibited form a small peptide molecule is blocking the cutting edge of the molecular scissors. "With the peptide still in place we could peer below a previously impenetrable part of the cathepsin B structure ", explained Betzel. There, the analysis revealed significant differences between the peptide binding sites at the parasite's and the human form of cathepsin B. "This way, nature provided us with a blueprint of what an artificial inhibitor for the parasite's enzyme could look like." The next step would be to synthesise such a tailor-made plug and test it in the lab.

The molecular structure of the enzyme was solved to the atomic level by shooting bright X-ray flashes at the tiny cathepsin B crystals, which were only about a micron (a thousandth of a millimetre) in diameter and about ten microns long on average. Crystals scatter X-rays in a characteristic way that depends on their inner structure. From the resulting diffraction pattern the structure of the crystals can be calculated, in this case revealing the structure of the enzyme. Today, crystallography is a standard technique to analyse biomolecules. Usually, scientists use modified bacteria to produce biomolecules in large amounts and try to crystallise them into the largest possible sizes of high-quality crystals afterwards. The in vivo crystallisation pioneered at the labs of Betzel and Prof. Michael Duszenko at the University of Tbingen, who is also a member of the research team, employs living cells to produce crystals. In contrast to standard crystallisation experiments, only in vivo crystallisation yielded suitable crystals of cathepsin B in a natively inhibited form.

But the in vivo crystals are still so small that only X-ray lasers like LCLS are bright enough to produce sufficiently detailed diffraction images. The LCLS belongs to a novel class of scientific light sources called free-electron lasers that are based on powerful particle accelerators. In these machines, electrons are accelerated to high speeds, or energies, and are then forced on a tight slalom course. In every bend each electron emits a tiny flash, and all the flashes add up to an incredibly strong X-ray pulse with laser properties, that allows to resolve structures like the natively inhibited cathepsin B molecule.

To solve the cathepsin B structure the researchers had to record hundreds of thousands of diffraction images that were painstakingly stitched together afterwards. As each crystal is destroyed when hit by the powerful X-ray flash, the team fed a stream of crystals in a watery solution through a thin nozzle into the laser path. The X-ray laser fired away at 120 shots per second, where on average only every eleventh shot actually hit a crystal. This resulted in a total of 293,195 diffraction images recorded. These could only be processed with massive parallel computing, to first generate a three-dimensional map of the entire diffracting signals of the enzyme from which an image of its structure was calculated. The final result revealed the enzyme's structure with a resolution of 2.1 ngstrm (one ngstrm is a tenth of a nanometre or a ten-millionth of a millimetre). "Interestingly, this discovery comes exactly at the centenary of the publication of the famous X-ray diffraction equation by William Bragg in 1912," Chapman pointed out.

The team included members from DESY, the Universities of Hamburg, Lbeck, Tbingen, Uppsala and Gothenburg, the Arizona State University, SLAC, Lawrence Livermore National Laboratory, the Max Planck institute for medical research in Heidelberg and the Max Planck advanced study group at CFEL. CFEL is a joint venture of DESY, the Max Planck society and the University of Hamburg. DESY is the leading German accelerator centre and one of the leading worldwide.

###

Reference: "Natively inhibited Trypanosoma brucei cathepsin B structure determined using an x-ray laser"; Lars Redecke, Karol Nass et al.; Science, 2012 (advance online publication); DOI: 10.1126/science.1229663


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-11/haog-xeb112612.php

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Financial Services Roundtable Joins Up With Homeowner Group to ...

It?s not often that the homeowner advocates at the Center for Responsible Lending and the bank lobbyists at the Financial Services Roundtable agree on anything. But they?re teaming up on urging Congress to extend the Mortgage Forgiveness Debt Relief Act, which would continue the foreclosure crisis-era policy of forgiving payment of taxes on debt forgiveness like a principal reduction or a short sale.

In letters to the Senate Finance Committee and the House Ways and Means Committee, which have jurisdiction over tax law, CRL and the FSR describe the debt relief law as ?critical to helping homeowners and communities struggling with the ongoing foreclosure crisis.? They also note that failing to extend the law would threaten a housing recovery.

As I?ve been writing, if Congress fails to extend the MFDRA, come January 1, every homeowner receiving debt relief on their mortgages, through either principal forgiveness or short sale, would see that forgiven debt count as earned income for tax purposes. Borrowers could plead tax insolvency to exempt themselves from the tax liability, but that?s a bruising process. The resulting tax liability would make borrowers extremely unlikely to accept the terms of any debt forgiveness, as it would cost them too much on the back end. Struggling homeowners don?t typically have $50,000 lying around to pay the federal government after getting a break on the principal balance on their home.

The Financial Services Roundtable, now under the direction of Tim Pawlenty, likes the law because it facilitates those short sales, which have been booming of late. Short sales are one of several housing policies that are actually beneficial for all sides. The homeowner doesn?t go through foreclosure and gets to sell their home without incurring a debt as they otherwise would; the bank gets a higher price for the home than it would if it fell into foreclosure, and a more streamlined process where they never have to take ownership. Principal reduction happens to be beneficial for all sides as well relative to foreclosure, but banks have resisted it because it represents a bigger loss for them. Still, failure to extend the MFDRA would have the effect of stalling out BOTH of these options.

As for the foreclosure fraud settlement in place that mandates debt forgiveness up to a certain level, this expiration would effectively cancel it. The borrower would owe so much in taxes, they would never assent to taking the debt relief.

The Senate Finance Committee passed a one-year extension as part of a larger ?tax extenders? bill, but despite bipartisan support, they have not been able to move that bill to the floor, and it has similarly gone nowhere in the House. And time is running out. Having the Financial Services Roundtable on board with what is a priority for homeowner advocates makes passage slightly more likely, but if you know anything about the 112th Congress, you wouldn?t use the word ?likely? about anything.

Source: http://news.firedoglake.com/2012/11/29/financial-services-roundtable-joins-up-with-homeowner-group-to-urge-extension-of-mortgage-debt-forgiveness-tax-relief/

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Pre-caffeine tech: Gold LEGO, Facebook law!

Featured

18 hrs.

Drone from University of Nebraska-Lincoln

Celebrity gossip site TMZ found itself on the other side of the rumor mill Tuesday morning, after a story claimed it?applied for a surveill... Read more

3 hrs.

Here's everything that you need to know before taking that first sip of coffee today.

Consumer Reports' annual ratings of wireless providers, released Thursday, shows that the major cellphone companies still have a lot of work to do to boost customer satisfaction. (AT&T is the worst!)

Celebrity gossip site TMZ found itself on the other side of the rumor mill Tuesday, after a story claimed it?applied for a surveillance drone permit from the Federal Aviation Administration. Here's what you need to know about drones n' journalism!?

Google hacked in Romania and Pakistan? Ummmm ... not quite.

Speaking of Google, the guy in charge of Google+ said ads on Facebook are like sandwich boards and nobody cares.?

Speaking of Facebook ... remember last week's freakout about Facebook copyright issues? Here's a quick review of Facebook Law for Idiots.

The world?s most expensive LEGO is a $14,500 solid gold brick.

Speaking of holiday shopping, check out the heaviest thing you can get Amazon to ship you for FREE! (It weighs nearly a ton!)

If you ever get?arrested for child porn, Ars Technica advises that you?don't e-mail threats to rape and kill a federal agent.

Here are the top 100 most popular songs of 2012, according to Spotify!?

Oh, and hey Internet Explorer haters! Microsoft is totally trolling you.

In closing, here's concrete proof that Jeremy Renner (aka "Hurt Locker" aka "Nighthawk") is actually Grumpy Cat.?

? compiled by Helen A.S.?Popkin, who invites you to join her on?Twitter?and/or?Facebook.?Also,?Google+.

Source: http://www.nbcnews.com/technology/technolog/pre-caffeine-tech-gold-lego-facebook-law-1C7325954

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Thursday, November 29, 2012

Somali Islamist militants slam soldier abuse video

NAIROBI, Kenya (AP) ? A video that appears to show Kenyan troops beating militant suspects has opened the force to criticism from al-Qaeda-linked militants who are known for carrying out harsh punishments like stonings, amputations and beheadings.

An al-Shabab spokesman claimed on Twitter that a video obtained by a Kenyan TV station shows Kenyan troops abusing Muslims. The spokesman said the video shows that Kenyan troops are waging war on Islam.

Kenyan military spokesman Col. Cyrus Oguna said Thursday that investigations are being conducted to find out the identity of the men in the video. Soldiers surround two suspects and beat them with sticks while asking questions about al-Shabab in Swahili, the main language spoken in Kenya.

Kenya sent troops to Somalia last year to pursue al-Shabab rebels after a wave of cross-border attacks.

Source: http://news.yahoo.com/somali-islamist-militants-slam-soldier-abuse-video-130734575.html

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Getting The Word Out About You On The Internet | Articlexone free ...

Hold a contest where the entry method is supplying a testimonial for your product, and then use those testimonials throughout your website. This is especially effective if you ask for video testimonials as a person is so much more believable when you can see their body language and relate to them.

Use buttons! For internet marketing to make your web pages load faster cut down on banner ads, instead use more button ads. Button ads are smaller and take up less space! Since people often ignore banner ads anyway, they will get you more business!

While using e-mail as a form of internet marketing still works in certain niches, be aware to whom you are sending an internet marketing email! You do not want to send it to the wrong clients. Setting up your own e-mail to have client groups and using last names instead of first are a few quick ideas to make sure you don?t send the wrong advertising to the wrong people.

One way to make your online presence more viral is to give something away for free. Be it samples, a contest for products or services or some other freebie, publicizing something for free will greatly increase the chances that your links will get passed on to others. This will end up raising your online visibility, exponentially.

Unless you are marketing a well-known national brand, you may only have one chance to convert a site visitor into a paying customer. Check all links on your site to ensure that there are no breaks in navigation or info transmission; this is especially true if you are marketing luxury goods or high-dollar items.

Include testimonials somewhere on your website. Having customer?s feedback readily available for other potential customers to see, can give your readers, a different view on what other people have thought about your product. When they can read good reviews about other people?s experience, this will make them feel more reassured when they want to try the product, as well.

Be sure that you are using meta and title tags wisely. It is a general rule that you should not repeat any more than 20% of description and meta tags on each page. Also, do not use too many characters in your title tag ? it will put the reader off.

It?s easy to get in a lot of tax trouble if you?re operating an online business. Before your internet marketing efforts really pay off, make sure you receive all proper tax documentation and thoroughly go over your earnings and expenses. In the world we live in today, a murderer can walk free but a tax cheat is going to prison.

To help your business internet marketing, make sure your website is user friendly. You might think it looks good, but try it on different computers and with multiple browsers. Sometimes certain features are disabled on various browsers, and this might affect how much content your viewer has access too, as well as how long they will look around the site. Keep things simple and easy to find.

Facebook has become one of the best ways to promote your company online. Hundreds of millions of people worldwide use Facebook on a daily basis, granting you huge amounts of exposure to a large client base. Since Facebook also has personal interests of every person, you can easily target a specific group.

There are a lot of online services that help you with internet marketing search engine tips. If you want your site to be indexed by Yahoo, Ask or Google, you are going to need to be quite selective with the keywords that you used. There are tools available through Google that will help you find the most successful keywords.

An interesting internet marketing tip is to use the ?bill me later? option for payment on products. Some people may view this as risky, but for the most part, people do end up paying their bills. This is a great way to get business from people who are short on funds at the moment.

Identify an overall meaning to the articles that you use for internet marketing. You want to have a special message that is sent in each article or every internet campaign you put on, then your customers and target customers are able to see what you are all about. Is there something special that you want to share? This should be included.

As stated at the beginning, there is quite a bit of information in regards to internet marketing. Hopefully you will find these tips beneficial. You should now find yourself ahead of the game if you are working to become an expert, or just trying to get a bit of background information.

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Source: http://articlexone.com/getting-the-word-out-about-you-on-the-internet/

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Balloon test shows space tourism on horizon

7 hrs.

Not all space tourism is rocket science. A newly successful test of a balloon could allow paying human customers to enjoy stunning Earth views and the weightless astronaut experience by 2014.?

The test balloon carried a humanoid robot up to an altitude of almost 20 miles (32 kilometers) on Nov. 12 ? just a few miles shy of where skydiver Felix Baumgartner leaped from during his "space dive" in October. Startup Zero 2 Infinity wants to eventually offer hours of flight time for space tourists to do whatever they want in a near-space environment.?

"Some people will want to tweet," said Jose Mariano Lopez-Urdiales, founder and CEO of Zero 2 Infinity. "Some will want to put down a carpet and pray to mecca. Some people will want to eat their favorite buffalo wings while they're up there."

Video: Near-space balloon soars in flight test

The Spanish company already has customers on its wait list?who paid an early deposit of almost $13,000 (10,000 euros) as the first installment out of a total ticket price of $143,000 (110,000 euros). It has also attracted funding from the world's second-largest balloon manufacturer, Spain's third-largest bank, and several angel investors by proving its concept step-by-step and by relying on proven helium balloon technologies.?

Flight testing took place at an Air Force base near Virgen del Camino in Spain. But Lopez-Urdiales envisions future flights launching from many other locations in the country.?

The balloon experience?
A typical predawn flight would take several hours to reach maximum altitude, so that passengers could enjoy seeing the sun rise against the blackness of space and see the curvature of the planet Earth. Luckily, the balloon would not need to get anywhere near the 62-mile (100 km) altitude that marks the official edge of space for its riders to enjoy stellar views.?

"You would spend two hours at the floating altitude of 36 kilometers (22 miles)," Lopez-Urdiales told TechNewsDaily. "We could do it higher, but it would not make any difference, because you already see the same visual cues at 39 kilometers or even 100 kilometers."?

Getting back down would mean cutting the cord between the balloon and the enclosed passenger capsule. Passengers could experience about 40 to 60 seconds of weightlessness during free fall, before parachutes and a parafoil carried them safely down to Earth.?

The recent test flight gave Zero 2 Infinity its first successful test of a balloon capsule large enough to carry humans, but only if the two people spent the entire trip lying down. An earlier flight test scheduled in May was canceled after?wind gusts damaged the test balloon.?

Robot test pilots?
Future versions of the balloons, called "bloons" by the company, would have donut- or bagel-shaped capsules with plenty of standing room for two pilots and four passengers. But the test capsule proved just right for the humanoid robot named Nao ? made by Aldebaran Robotics ? that stands at knee-height compared to adult humans.?

The robot rode as a passive passenger, but could someday become an active pilot that tests the controls and life-support technologies meant for humans.?

"Little by little, we're teaching it how to pilot, but that's at a very early stage," Lopez-Urdiales explained. "The idea in the future is to have?humanoid robots?testing future complex aerospace vehicles."?

The company has almost finished building a bigger test balloon that could comfortably carry two people standing up. That larger balloon could make an attempt at breaking the manned high-altitude balloon record set in the 1960s ? a record that requires the pilot to take off and land in the balloon. (Space diver Baumgartner intentionally disqualified himself by leaping out of his high-flying balloon.)?

The inner journey?
But Zero 2 Infinity doesn't just want to make money. Lopez-Urdiales envisions his balloons carrying scientific experiments or scientists high into Earth's atmosphere. His inspiration for creating the startup company came from his dad, an astrophysicist who worked on an experiment that went with the Cassini-Huygens mission to Saturn's moon Titan.?

"I was growing up around balloons, rockets and telescopes," Lopez-Urdiales said. "My dad tested a Huygens scientific instrument on a high-altitude balloon."?

The balloon space tourism's relatively more affordable price tag could also open the eyes of many more people through the "overview effect," Lopez-Urdiales said. Frank White, a communications director at Harvard's Kennedy School of Government, coined the term to describe how astronauts gained a better appreciation of global and environmental issues after seeing the Earth surrounded by the darkness of space.?

"That's probably the biggest benefit?private spaceflight?will offer to civilians and members of the public," Lopez-Urdiales said. "The overview effect is personal experience, but then you share it. I think it goes a much longer way than bragging rights."?

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Source: http://www.nbcnews.com/travel/itineraries/balloon-test-shows-space-tourism-horizon-1C7290082

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