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NYUCD receives grant to identify biomarkers for the progression of periodontal diseasePublic release date: 31-May-2012 [ | E-mail | Share ]
Contact: Christopher James christopher.james@nyu.edu 212-998-6876 New York University
New York University College of Dentistry has been selected as one of five institutions that are sharing a $20.7 million grant from the National Institute of Dental and Craniofacial Research (NIH) to the Forsyth Institute to find new ways to diagnose and fight periodontal disease. As the recipient of a $1.8 million subcontract, the NYU College of Dentistry will screen research subjects and collect biological samples that will contribute to the overall project, "Biomarkers of Periodontal Disease Progression."
This major, five-year project, involving 500 subjects across all sites, explores periodontal disease from the microbiological, genetic, and immunological perspectives. The goals are to expand the use of biomarkers to understand why people develop periodontal disease, under which circumstances the disease is most likely to progress, and how periodontal treatment impacts patients' biomarkers.
To varying degrees, periodontal disease affects 40 percent of adults in the United States and can lead to loss of bone that supports the teeth. NYU will focus on identifying biomarkers among 75 subjects with periodontal disease compared with 25 control subjects.
In December 2011, NYU began to collect clinical indicators and biological samples such as saliva, plaque, and gingival crevicular fluid from research subjects. It will send these samples to the Forsyth Institute for analysis to identify biomarkers. The Forsyth Institute is an independent research organization that focuses on oral health.
"Biomarkers are factors in people's blood, dental plaque, saliva, or tissue that might indicate that they are more susceptible than others to developing periodontal disease," says Dr. Patricia Corby, principal investigator on the NYU College of Dentistry grant and assistant professor of periodontology and implant dentistry and associate director of the NYU Bluestone Center for Clinical Research. "By identifying these factors, we will be able to design more specific treatments for this condition; thus we're changing the paradigm of how we diagnose and treat periodontal disease."
A traditional biomarker for periodontal disease is bleeding on probing. Other biomarkers include a high degree of disease-associated bacterial colonization affecting the tissues that surround and support the teeth or the presence of cytokinestypes of proteins that are secreted by numerous cells in the body, which are associated with inflammation. Biomarkers may indicate the presence or absence of periodontal pathogens, gingival and periodontal inflammation, an inflammatory-immune response to certain pathogens, or tissue destruction.
Although these biomarkers can be associated with periodontal disease, they also can be associated with other systemic diseases. To isolate biomarkers for periodontal disease, researchers will exclude any patients with other systemic diseases such as heart disease or diabetes. Because so many periodontal patients do have comorbidities, the researchers expect to screen 10 subjects for each one who fits the criteria.
In addition to looking for biomarkers through this study, researchers are exploring a novel approach to treat periodontal disease. According to Dr. Corby, periodontists generally treat the entire mouth with scaling and root planingunder the assumption that the entire mouth is affected or as a preventive treatment approach. Research at the Forsyth Institute has shown that progression of the disease is site-specific as well as episodic. Patients may do well with a more conservative approach to treatment and steady monitoring to determine whether and where the disease is progressing, says Dr. Corby. Patients in the study will return every two months for monitoring of specific sites and to see whether changes have occurred. In places where the disease is advancing, researchers will treat only the parts of the mouth that are progressing toward disease.
"We want to look at people who respond to this therapy and see how their biomarkers change due to the therapy that we're proposing," says Dr. Corby, noting that the presence of certain biomarker microbes might make some sites in the mouth progress more quickly than others. "If the study succeeds (and this is a preliminary trial), it might change the way the profession treats periodontal disease."
A theory underpinning the study is that periodontal disease is not just a chronic infection, as was once thought, but is related as much, if not more, to inflammation and other immune-system functions. Understanding the biomarkers for inflammation that are associated with periodontal disease will help determine how to treat people.
In addition to Dr. Corby, co-investigators from the NYU College of Dentistry include Dr. Robert Schoor, clinical associate professor of periodontology and implant dentistry and director of the Advanced Education Program in Periodontics; Ms. Rosemary Hays, clinical associate professor of dental hygiene and assistant academic director of the dental hygiene program; Ms. Cynthia J. Howard, clinical assistant professor of dental hygiene and junior research scientist at the NYU Bluestone Center for Clinical Research; and Ms. Judith Kreismann, clinical associate professor of dental hygiene.
The overall project is led by Dr. Richard Teles, a senior member of the staff at the Forsyth Institute and director of the Center for Clinical and Translational Research at Forsyth. Dr. Teles hopes ultimately to develop diagnostic tests to help identify subjects and sites in the mouth that are most susceptible to periodontal disease progression.
###
About New York University College of Dentistry
Founded in 1865, New York University College of Dentistry (NYUCD) is the third oldest and the largest dental school in the US, educating more than 8 percent of all dentists. NYUCD has a significant global reach and provides a level of national and international diversity among its students that is unmatched by any other dental school.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
NYUCD receives grant to identify biomarkers for the progression of periodontal diseasePublic release date: 31-May-2012 [ | E-mail | Share ]
Contact: Christopher James christopher.james@nyu.edu 212-998-6876 New York University
New York University College of Dentistry has been selected as one of five institutions that are sharing a $20.7 million grant from the National Institute of Dental and Craniofacial Research (NIH) to the Forsyth Institute to find new ways to diagnose and fight periodontal disease. As the recipient of a $1.8 million subcontract, the NYU College of Dentistry will screen research subjects and collect biological samples that will contribute to the overall project, "Biomarkers of Periodontal Disease Progression."
This major, five-year project, involving 500 subjects across all sites, explores periodontal disease from the microbiological, genetic, and immunological perspectives. The goals are to expand the use of biomarkers to understand why people develop periodontal disease, under which circumstances the disease is most likely to progress, and how periodontal treatment impacts patients' biomarkers.
To varying degrees, periodontal disease affects 40 percent of adults in the United States and can lead to loss of bone that supports the teeth. NYU will focus on identifying biomarkers among 75 subjects with periodontal disease compared with 25 control subjects.
In December 2011, NYU began to collect clinical indicators and biological samples such as saliva, plaque, and gingival crevicular fluid from research subjects. It will send these samples to the Forsyth Institute for analysis to identify biomarkers. The Forsyth Institute is an independent research organization that focuses on oral health.
"Biomarkers are factors in people's blood, dental plaque, saliva, or tissue that might indicate that they are more susceptible than others to developing periodontal disease," says Dr. Patricia Corby, principal investigator on the NYU College of Dentistry grant and assistant professor of periodontology and implant dentistry and associate director of the NYU Bluestone Center for Clinical Research. "By identifying these factors, we will be able to design more specific treatments for this condition; thus we're changing the paradigm of how we diagnose and treat periodontal disease."
A traditional biomarker for periodontal disease is bleeding on probing. Other biomarkers include a high degree of disease-associated bacterial colonization affecting the tissues that surround and support the teeth or the presence of cytokinestypes of proteins that are secreted by numerous cells in the body, which are associated with inflammation. Biomarkers may indicate the presence or absence of periodontal pathogens, gingival and periodontal inflammation, an inflammatory-immune response to certain pathogens, or tissue destruction.
Although these biomarkers can be associated with periodontal disease, they also can be associated with other systemic diseases. To isolate biomarkers for periodontal disease, researchers will exclude any patients with other systemic diseases such as heart disease or diabetes. Because so many periodontal patients do have comorbidities, the researchers expect to screen 10 subjects for each one who fits the criteria.
In addition to looking for biomarkers through this study, researchers are exploring a novel approach to treat periodontal disease. According to Dr. Corby, periodontists generally treat the entire mouth with scaling and root planingunder the assumption that the entire mouth is affected or as a preventive treatment approach. Research at the Forsyth Institute has shown that progression of the disease is site-specific as well as episodic. Patients may do well with a more conservative approach to treatment and steady monitoring to determine whether and where the disease is progressing, says Dr. Corby. Patients in the study will return every two months for monitoring of specific sites and to see whether changes have occurred. In places where the disease is advancing, researchers will treat only the parts of the mouth that are progressing toward disease.
"We want to look at people who respond to this therapy and see how their biomarkers change due to the therapy that we're proposing," says Dr. Corby, noting that the presence of certain biomarker microbes might make some sites in the mouth progress more quickly than others. "If the study succeeds (and this is a preliminary trial), it might change the way the profession treats periodontal disease."
A theory underpinning the study is that periodontal disease is not just a chronic infection, as was once thought, but is related as much, if not more, to inflammation and other immune-system functions. Understanding the biomarkers for inflammation that are associated with periodontal disease will help determine how to treat people.
In addition to Dr. Corby, co-investigators from the NYU College of Dentistry include Dr. Robert Schoor, clinical associate professor of periodontology and implant dentistry and director of the Advanced Education Program in Periodontics; Ms. Rosemary Hays, clinical associate professor of dental hygiene and assistant academic director of the dental hygiene program; Ms. Cynthia J. Howard, clinical assistant professor of dental hygiene and junior research scientist at the NYU Bluestone Center for Clinical Research; and Ms. Judith Kreismann, clinical associate professor of dental hygiene.
The overall project is led by Dr. Richard Teles, a senior member of the staff at the Forsyth Institute and director of the Center for Clinical and Translational Research at Forsyth. Dr. Teles hopes ultimately to develop diagnostic tests to help identify subjects and sites in the mouth that are most susceptible to periodontal disease progression.
###
About New York University College of Dentistry
Founded in 1865, New York University College of Dentistry (NYUCD) is the third oldest and the largest dental school in the US, educating more than 8 percent of all dentists. NYUCD has a significant global reach and provides a level of national and international diversity among its students that is unmatched by any other dental school.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
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So congratulations are so as. You will be significant this time. True, your body hasn?t gone completely south on you but Air Max and also you are only planning to shed about 8 pounds and company up that made use of to be three pack abs but your commitment is shining and vibrant and also you would like to locate oneself the most recent and best workout gear. Muddling via conditioning gear is actually a work out of its personal. Based on tv and print media reviews, everything on the market is not only probably the most productive and will give you with the fastest outcomes, however it can also be created by some tremendous warm shot NASA engineer and requires-get this-no effort in your part! How fabulous is that? All you?ve got to do is devote $300 to $3000 on the newest and very best and it?s going to do the function for you personally! I ought to be dedicated for going swimming 6 days a week.
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Following a story we wrote May, 8 2012 concerning a plan to replace 125 factory-built homes at the Wagon Wheel Village MHC in Box Elder, South Dakota with 166 modular units, we learn owner Bob Akers is returning to the Planning and Zoning Commission with revised plans, according to the RapidCityJournal. MHProNews.com has learned his original plan was to space the homes ten feet apart. The commission?s current statute does not address population density, but does require MH to be 20 feet apart. At the May 7 meeting commissioners had also expressed concerns regarding fire and police access, storm water drainage, parking, and useable outdoor space.
(Photo credit: MerchantCircle?Modular home under construction)
Categories: Communities, Factory-Built Homes, Legal, Manufactured Homes, Modular, News Item, ZoningTags: akers, box elder south dakota, mh, MHC, outdoor space, owner bob, population density, storm water drainage, ten feet, wagon wheel village, wheel, zoning commission
When most people think about the various duties related to managing a retail store or chain, the checkout lane is among the first thoughts in their head. The customer?s experience at the point of sale and the business?s ability to provide an accurate, efficient, and enjoyable sales experience will determine the success of the business in a large way. The point of sale is also an important part of retail business because it?s an important place to collect data on customers and their purchases. If you?re looking for a solution to managing your retail business the right way, consider looking into ChainDrive?s retail management software package. It includes a Point of Sale component with advanced features and settings that help you meet the specific needs of your business. It?s a great way to increase productivity while simultaneously improving upon your customers? experience in your store(s).
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Retail managers will be able to toggle security settings in the Point of Sale module so that only certain employees have access to certain actions and features. This ensures that the order and security of your business is intact.
Get ChainDrive?s Point of Sale software and improve your retail business!
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Hey, look at that. The long-awaited Android 4.0.4 update for the Verizon Galaxy Nexus now has an official support page at Big Red's site. That's just one more step closer to an actual OTA update, and it can't come soon enough. Here's the full changelog for IMM76K:
Email, Messaging & Data
Email messages will display properly when the text size is set to large.
When sending a multimedia message to an Outlook email address, the file extension
will send, allowing the recipient to successfully open an image.
Successfully deleted emails on the device will be deleted from the desktop as well.
Successfully send text messages without experiencing network connectivity issues.
Applications
When viewing a Calendar reminder or appointment, you will now be able to view the full notes associated with the appointment.
A down arrow has been added in the Calendar application that will expand the calendar message body, allowing you to view the entire message.
Device Features
Successfully turn on Wi-Fi using the Power Control widget.
Updates have been made to prevent the display from freezing or becoming unresponsive.
Complete calls without experiencing choppy audio, clicking noises and one-way audio noises.
Successfully access Voicemail and other automated systems without error.
Now all we need is, ya know, the update to actually push. Keep your eyes peeled, folks.
Considered once self-indulgence, club appointments are actually more and more regarded as inside important a part of the kitchen connoisseur program. By simply alleviating strain, calming painful systems as well as removing harmful poisons, schools art emotive, physical and mental well-being because of their devoted enthusiasts.
For this reason craze in the direction of health and fitness, many schools described greater sessions as well as profits throughout the This year economic depression. Nevertheless this particular occurrence carries a number of various effects pertaining to day spa entrepreneurs along with professionals. Since the availability of day spa companies stretches, you can find almost always far more clientele for you to fill up a person's training, just about all signifies that annually, the quantity of fighting organizations magnifies!
Essentially the most beneficial useful resource in which club online marketers possess will be the electrical power that belongs to them experience. Responding in order to soaring healthcare expenses as well as developing understanding complementary medicine, People in the usa nowadays are generally voraciously consuming a content article of knowledge possible upon alternative curing and also health and fitness. They may be training them selves as well as getting aggressive regarding health insurance and physical appearance inside your.
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Exactly how do you consider the market know-how as well as transform in to a greater customers and also profits flow?? By utilizing interpersonal as well as one on one marketing strategies to coach your neighborhood local community in regards to the many benefits of the companies! Merely go through the present files about day spa patronage as well as understand what to do to work with this information in your advertising edge:
Truth: You can find Thirty two trillion energetic spa-goers in the usa.
Think! There are other compared to adequate consumers for everyone its your professionals out and about there- but wait, how would you arranged on your own separate? It will become significantly fundamental to supply a area of interest plan to the focused viewers. Exactly what is a area of interest program and also audience? Look at this case in point: A single day spa practitioner or healthcare provider may develop a club package deal designed for spoiling brand-new moms. They may possibly contemplate aimed towards brand new parents simply by developing proper alliances together with morning cares for you, Doulas, mid-wives, child shops, Lamaze lecturers, and also expectant mothers retailers to handle package deal literature and gives deals with their consumers!
Simple fact: Lowering or perhaps alleviating strain will be the # 1 cause men and women head to schools.
Strain is the better outbreak in the usa, triggering a great number of both mental and physical issues. Employ this data in your favor along with promote solutions to lessen force on your web site along with your current e-zine. Any time viewers view you just as one professional whom offers ideas and knowledge, they'll benefit anyone as being a source. This particular strategy on it's own will raise the probability that they can use anyone within the future-or on the least-refer one to relatives and buddies!
Reality: Health care schools are still your fastest-growing part inside the club business.
How do you benefit from this specific development less than transforming into a certified medical professional? As increasing numbers of clients turn to the most up-to-date healthcare technologies to take a look as well as feel good, think about tactical partnership using a skin doctor or perhaps health care worker doctor to reinforce marketing package deal. A lot of providers for example injectables along with filler injections can be carried out within day spa suites together with small adjustments. Discover a medical professional who's trying to increase his or her apply by simply to arrive to be able to support customers weekly, and then sell bundles which include each healthcare as well as rest remedies jointly!
Reality: As well as treatment method suites, 93% associated with health spas have a list area, along with retail store revenue makes up about 11% % regarding complete health spa profits.
It won't have a large monetary expenditure to incorporate a new retail store room with your establishment-in reality it can be simpler as compared to you believe. List room is surely an instance of your miracles involving A second income principle: displaying items in your clientele that may profit all of them requires with out which enable it to significantly raise your profits! In case you lack a big location to be able to devote, any counter-top room using a "call for you to action" (like a unique value about goods effectively frameworked) is extremely efficient for the people impulsive consumers. Suppose there is a cell club corporations and also function your own exercise mostly coming from a web site? Such as a no cost goods web site is easy from web sites including Cafepress or perhaps Etsy. You could make a web link from a how do people these kind of internet pages, incorporate shopping cart software take a look at capabilities, along with the best part-you do not pay the particular from suppliers price tag for that goods anyone have till they offer!
The truly great media is the health-related important things about any day spa routine hasn't ever recently been since widely known or perhaps advertised since it is right now! Rely on the actual power along with significance of the services you receive. Widen the particular good thing about your own club your clients' needs this returns of standard sessions in order to consumers currently!
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Asked onstage by Walt Mossberg and Kara Swisher about what could be done about the lack of Facebook integration on iOS despite it's formidable 900 million uses, as well as other stalls in the Apple and Facebook relationship (Ping anyone?), Apple CEO Tim Cook mysteriously replied, "Stay tuned." Multiple times. "Facebook is a great company." Cook said, "And the relationship is solid. I saw Sheryl (Sandberg) earlier outside. We have great respect for each other."
The expectant actress - who will deliver baby no. 4 in September - spent Memorial Day stylishly sunning her belly in a crocheted suit, orange necklace and Sanuk sandals.
A comment ?exposure to tobacco smoke and chronic diseases of childhood,? even in the printed version in July , discusses the results of both studies and the need to promote programs to quit smoking to educate parents about the dangers of tobacco exposure through the development of children, even prenatally.Additional variables that were associated with these disorders include the use of levodopa, another treatment for Parkinson?s disease, who live in the United States are younger and single, smoking cigarettes and with a family history of gambling problems
The study, ?Maternal smoking and psychological problems of children: Untangling the causal effects and not causal,? has found an association between maternal smoking during pregnancy and mental health of children, especially externalizing behavior and behavior problems. The study, ?Smoking is associated with paternal overweight in children: the views of? Children of 1997 ?birth cohort of Hong Kong,? found that paternal smoking may be related to the child increases index , even if the mother is not pregnant smokes.
Note: an independent study, ?Disparities in children?s exposure to tobacco smoke in the United States, 2007,? also appears in the print version of Pediatrics in July.
Rocking Apple?s iPhone 4? ? In that case you may want to head to Settings > General > Software Update, and pick-up iOS 5.1.1(9B208).
Released on Friday, the new build of software has been specifically designed for the GSM model of Apple?s iPhone 4, was compiled by the company last Thursday, and it is so far unclear just what the build changes or adds.
- Sponsors -
Available OTA (Over The Air), some are now speculating that the build?s release could signal that Apple is already working to patch the recently-released Absinthe 2.0 jailbreak. Although, we imagine that if this was the case, Apple would issue an update to all iOS devices ? (not just the iPhone 4).
Further efforts to prevent the porting of Siri? ? Perhaps.
DOWNLOADS
Download iOS 5.1.1 (9B208) directly from Apple.com.
Dirk Bezemer ? Credit is What Credit Does: Finance and Economic Growth Uncoupled
Contrary to conventional wisdom economics is not about money. ?The cutting edge models have no banking sectors at all,? says Dutch economist and INET grantee Dirk Bezemer. ?Models that central banks use have no banks. Just let that sink in.?
Bezemer has conducted a careful analysis of the financial sector that provides a much-needed change from the usual macroeconomic models. In his recent presentation at INET Berlin, Bezemer gave an in-depth explanation of how to create a socially useful financial system.
His answer is simple: ?Credit is what credit does.??
?Most of our credit system does not support economic growth in the sense of supporting transactions in goods and services,? he explains. ?Most of our finance system, most bank loans, support increased asset prices, which have a number of detrimental effects on the economy.??
Debt going to asset markets can be helpful at a low level of debt (when overall debt is about 100% of GDP, Bezemer suggests. The U.S., by comparison, is now at more than 400%.). But when debt gets too high, servicing it becomes a big drain on the real economy. And this means lower economic growth.?
But orthodox macroeconomic models won?t tell you any of this. ?There are no models tracing credit, so a credit crisis will come out the blue,? Bezemer says. ?We can do better than that.? Bezemer shows that ?on average, at higher levels of credit going to asset markets, there is a negative, inverse relation between international financial flows and fixed capital formation. And therefore you have lower growth.??
Supporting this credit addiction has very obvious symptoms. ?It?s not a coincidence that we have excessive speculation in food prices right now,? he says. ?All that money is still around.? The solution, according to Bezemer, is pretty simple. We must greatly shrink the financial sector, while preserving the essential functions of credit allocation to the real economy. As Bezemer writes in his recent article for Eurointelligence, ?The threat to growth today is not a shrinking of the financial sector, but it enormous size.?
Read the rest at INET Credit is What Credit Does: Finance and Economic Growth Uncoupled
Posted by INET
Also?Finance and economic growth delinked by Dirk Bezemer at Euro Intelligence
Question by Yay Ah!: Generally speaking, do most 401k plans allow the participant to invest in individual stocks? And by individual stocks, I don?t mean the company?s stock. I?m talking about non-employer stocks traded on an exchange.
In addition, do most 401k plans allow the participant invest in any mutual fund of his/her choice? Or do most 401k plans offer only a limited mutual fund selection?
*I know plans vary. But, this is just a general question.
Best answer:
Answer by Sean Roberts Adam, A 401K is like a shopping cart in a supermarket. You can buy any type of investment from a stable stock such as Exxon to a speculative venture capital stock, to a mutual fund, to a corporate bond, to a municipal bond, or anything else. I would advise you to diversify your portfolio as much as possible. You are not obligated to buy stock in your employer?s company.
A 401K is handled by a third party investment firm. Your company only knows how much you have contributed to your 401K, but not what you bought with it.
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This file photo shows a new home for sale in Winter Garden, Fla. U.S. home prices edged higher in most major cities for the second straight month.
By msnbc.com staff and news wires
U.S. single-family home prices edged higher in March, the second month of gains in a row, adding?to signs the housing market is stabilizing, a closely watched survey said on Tuesday.
The S&P/Case Shiller composite index of 20 metropolitan areas gained 0.1 percent in March on a seasonally adjusted basis, falling shy of economists' forecasts for a gain of 0.2 percent.
On an unadjusted basis, the index was unchanged. Prices in the 20 cities were down 2.6 percent year over year, improving from the 3.5 percent yearly decline seen last month.
Still, the major indexes ended the first quarter at new post-crisis lows, the report said. For the first quarter, prices were down 2 percent, compared to a 3.9 percent decline in the last three months of 2011.
Tuesday's data was another piece of evidence recently that the housing market is?making a bumpy revival. The median price for a new home rose 4.9 percent in April, year over year, while sales of existing homes rose 10 percent last month versus April 2011.
"In my mind there is no question that housing has bottomed, in terms of home sales, home construction and home prices but the recovery is still going to be very modest or very sluggish," said Mark Vitner, senior economist for Wells Fargo Securities.
Housing has a long way to go, though. Nearly 16 million homeowners owed more on their mortgages than their home was worth in the first quarter, or nearly one-third of U.S. homeowners with mortgages.
"There are still so many unanswered questions in front of us, such as what has happened to attitudes toward home ownership. We know there has been some change to that. Also we don't know what is going to happen with Fannie Mae and Freddie Mac, what is the government's role in mortgage financing going to be? We are not going to be able to settle that until after the election," Vitner said.
In a new survey of 6,022 small businesses across the U.S., Oklahoma, Idaho, and Texas earned A+?s for their overall friendliness toward small businesses. Top performing cities included Oklahoma City, Dallas-Ft. Worth.
Oklahoma earned As in 10 of 12 graded categories, ranking third in overall friendliness, fourth in ease of starting a new business, and sixth in least costly state for hiring a new employee.
Oklahoma also ranked sixth in optimism about the future, 11th in current economic health, and 18th in growth rate last year.
Thumbtack.com, in partnership with the Ewing Marion Kauffman Foundation (EMKF), conducted the Thumbtack.com Small Business Survey, which draw on considerable data from small business owners themselves.
California, received an F in friendliness and Fs and Ds in 10 of 12 categories. Massachusetts earned Ds in nine of 12 categories, including overall friendliness. New York also earned a D in friendliness and Ds or Fs in seven other categories.
Survey respondents ranked licensing requirements were nearly twice as important as tax-related regulations in determining over all friendliness. An important predictor of small business friendliness was where small business owners are aware of the state of local government offering training programs for small businesses.
While it?s great to get a top ranking compared to other states in terms of friendliness and easy of doing business, it remains a fact that a huge percentage of the entrepreneurial activity in the U.S. continues to occur in Boston, New York, and Silicon Valley.
According to the Halo Report, published by the Angel Resource Institute, CB Insights, and Silicon Valley Bank, California, New York, and New England account for nearly 50 percent of angel group deals and dollars invested.
So, it seems to me that the results of a survey like this gives Oklahoma a little something to crow about and something larger to think about. For example:
How can we capitalize on our reputation as a state that is friendly, cost effective, and an easy place for small companies to do business, to create jobs?
What are the additional ingredients in California, New York, and Boston that cause entrepreneurs to continue to start companies and investors to keep investing in spite of an environment is deemed so unwelcoming by some many? A highly educated workforce? Ready sources of capital? Cashed-out entrepreneurs who mentor their juniors?
Is there some kind of a trend developing? Are friendliness and ease of doing business starting to matter more to entrepreneurs?
For full survey results and methodology, click here.
Home buyers need resources in the current day's market place if they hope to find the sweetest deals on properties. Articles like the one you're reading now, are all about pointing you in the right direction and giving you a great deal of beneficial tips that you can use, to make the right call. And don't forget to check with a real estate lawyer should you face any aspects of a property exchange that you don't understand.
When buying a home, put down at least twenty percent of the house?s selling price as your down-payment. If you put down less than this amount, you'll often be need to buy non-public mortgage insurance (PMI). This fee is around half of a %, which would be about $1000 a year on a $200,000 house.
Understand the diversities between all the differing kinds of mortgage loans that are out there. Because there are many various options available when it comes to loans, you want to be certain to make the right choice for you and your folks. By doing your research, you'll be capable of making a sensible decision.
Never start a property negotiation by making a low-ball offer you do not expect to pay. Your opening bid should invariably be a reasonable price. Low-balling divides the seller your are dealing with, and sets a combative tone for the remainder of the negotiation. It's much better by far to keep the entire sales process easy and honest.
Do not buy the 1st house you see and do not jump on a home because it is inexpensive or will close quickly. Do research, see other houses, and keep track of offers. By rushing into a purchase, you may skip steps like doing an inspection or buy something that you don?t actually like.
A key tip when buying real-estate is to be certain that you have a reputable real-estate agent. Your real-estate agent should be helping you review the documents and get you the best offer practical. If you sense that they are not the best at their job, it may be a good idea to find a new real-estate agent.
Home purchasers or any other kind of real estate shopper would do very well to aim for fixer-uppers in contrast to new, perfect homes. If you're prepared to provide the finishing touches on a property, you can save thousands upon thousands of bucks by putting in the work yourself. Purchasing brand new means you'll pay lots more.
When planning out how much house you can afford to buy, remember to work out in the maintenance costs of the home. Upkeep is one of the costliest factors in owning a home, but it's something many first time home purchasers will forget. Once you own the home, your property owner is no longer responsible if a pipe breaks, so economize for circumstances.
It?s all about making the right decision as a property buyer. If you're approaching buying without the correct information about the market, you could finish up losing money in a multitude of alternative ways. Use the tips that you have just learned here, to ensure that you purchase the best real-estate available.
Emory Somervale, author and counselor, recommends Atlanta real estate closing attorneys and Atlanta title companies.
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Public release date: 31-May-2012
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Following a story we wrote May, 8 2012 concerning a plan to replace 125 factory-built homes at the Wagon Wheel Village MHC in Box Elder, South Dakota with 166 modular units, we learn owner Bob Akers is returning to the Planning and Zoning Commission with revised plans, according to the RapidCityJournal. MHProNews.com has learned his original plan was to space the homes ten feet apart. The commission?s current statute does not address population density, but does require MH to be 20 feet apart. At the May 7 meeting commissioners had also expressed concerns regarding fire and police access, storm water drainage, parking, and useable outdoor space.
When most people think about the various duties related to managing a retail store or chain, the checkout lane is among the first thoughts in their head. The customer?s experience at the point of sale and the business?s ability to provide an accurate, efficient, and enjoyable sales experience will determine the success of the business in a large way. The point of sale is also an important part of retail business because it?s an important place to collect data on customers and their purchases. If you?re looking for a solution to managing your retail business the right way, consider looking into ChainDrive?s retail management software package. It includes a Point of Sale component with advanced features and settings that help you meet the specific needs of your business. It?s a great way to increase productivity while simultaneously improving upon your customers? experience in your store(s).
Asked onstage by Walt Mossberg and Kara Swisher about what could be done about the lack of Facebook integration on iOS despite it's formidable 900 million uses, as well as other stalls in the Apple and Facebook relationship (Ping anyone?), Apple CEO Tim Cook mysteriously replied, "Stay tuned." Multiple times. "Facebook is a great company." Cook said, "And the relationship is solid. I saw Sheryl (Sandberg) earlier outside. We have great respect for each other."
Thumbtack.com, in partnership with the Ewing Marion Kauffman Foundation (EMKF), conducted the Thumbtack.com Small Business Survey, which draw on considerable data from small business owners themselves.
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